神经梅毒患者的临床特征及神经电生理检测

目的：评价临床特征和神经电生理检测在神经梅毒诊断中的价值。方法：回顾性分析经临床和实验室检查确诊的10例神经梅毒病人的有关资料。结果：10例病人均为男性，平均年龄58岁，间质性梅毒占60％，CT／MRI表现以多发散在病灶多见，脑脊液检查50％病人细胞数升高，所有患者蛋白升高，脑脊液细胞学检查均异常，脑脊液梅毒螺旋体血凝试验(TPHA)均( )，60％快速血浆反应素试验(RPR)( )。EEG异常率为100％，而ERP的P300、VEP、BAEP亦有较高的异常率。结论：神经梅毒临床表现多样性，实验室检查是早期诊断的重要依据；神经电生理检测能提供临床及临床下损害的证据。

Value of clinical characteristics and electroneurophysiology in diagnosis of neurosyphilis

Objective: To assess the value of clinical characteristics and electroneurophysiology in the diagnosis of neurosyophilis. Methods: Retrospective study was performed in 10 patients with neu-rosyphilis. Result: All the patients were male ,whose average age was 58 years . Sixty percent of the pa tients were to suffer from interstitial neurosyphilis , CT/MRI scan of brain revealed multiple ,scattered lesions. An increased white blood cell number was found in 50% of and posive RPR in 60% of the patients . All the patients showed abnormal cytologic examination and TPHA(+ ) . The abnormality rate of EEG was 100%, and that of P300 of ERP, VEP and BAEP was much higher. Conclusions: Neu rosyphilis might show different clinical manifestations, the laboratory test might be in early diagnosis, Electroneurophysiology provide evidence for clinical and subclinical damage.