丹参在体外对血小板活化功能和PLT、MPV的影响

目的　探讨丹参在体外对血小板活化功能和血小板数 (plateletcount,PLT)、血小板平均体积 (meanplateletvolume ,MPV)的影响。方法　用流式细胞仪三色分析测定血小板表面激活标记物纤维蛋白原受体 (FIB R)和P 选择素(CD62 P)的表达 ;用CD170 0型血细胞分析仪测定PLT和MPV。结果　测定组的FIB R和CD62 P表达水平与PLT和MPV的值同对照组比较P >0 0 5 ,没有显著性差异。激活组的FIB R和CD62 P表达水平与PLT和MPV的值同对照组比较 ,P <0 0 5 ,有显著性差异。结论　丹参有保护血小板FIB R和CD62 P被活化 ,阻止血小板聚集 ,在血栓性疾病的防治中有积极作用。

The in vitro offect of salvia miltiorrhiza on platelet activation and PLT and MPV

Objective To study the action of Salvia miltiorrhiza in inhibiting platelet activation and platelet count(PLT) and mean platelet(MPV) in vitro Methods Salvia miltiorrhiza,which could inhibit the expression of fibrinogen receptor(FIB R) and P selectin(CD 62 P) on activated platelet surface in vitro,was analyzed by tri color flow cytomety PLT and MPV was determined by hematology analyzer Results Comparing the results of the studied group with those of the normal subject,We found that salvia miltiorrhiza could inhibit the expression of FIB R and CD 62 P( P >0 05) and that ADP could increase FIB R and CD 62 P( P <0 05) Conclusion Salvia miltiorrhiza can inhibit platelet activation and prevent platelet conglomeration,which is effective to prevent thrombus of platelet