Molecular pathology of chondroid neoplasms: part 1, benign lesions |
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Authors: | W C Bell M J Klein M J Pitt G P Siegal |
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Institution: | (1) Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA;(2) Departments of Pathology and Diagnostic Radiology, and the Center for Metabolic Bone Disease, University of Alabama at Birmingham, Birmingham, AL, USA;(3) Department of Diagnostic Radiology, and the Center for Metabolic Bone Disease, University of Alabama at Birmingham, Birmingham, AL, USA;(4) Departments of Pathology, Cell Biology, and Surgery, and the Center for Metabolic Bone Disease, University of Alabama at Birmingham, Birmingham, AL, USA |
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Abstract: | This two-part review presents an overview of the molecular findings associated with both benign and malignant chondroid neoplasms. This first part presents a brief review of methods in molecular pathology along with a review of the cytogenetic and molecular genetic findings in benign chondroid neoplasms. Clinical aspects of the various lesions are briefly discussed, and each tumor is illustrated with representative radiographic and pathologic images. Malignant chondroid neoplasms will be considered in the second part of this review.G.P. Siegal is supported by NIH grants CA93796, AR046031, CA098543 and the Haley’s Hope Memorial Support Fund for Osteosarcoma Research at the University of Alabama at Birmingham, USA. |
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Keywords: | Bizarre parosteal osteochondromatous proliferation Cytogenetics Molecular genetics Chondroma Chondromyxoid fibroma Chondroblastoma Osteochondroma |
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