Intercellular contacts in tumours of the vascular smooth muscle cells in man |
| |
Authors: | J. A. Sosa-Melgarejo C. L. Berry |
| |
Affiliation: | (1) Department of Morbid Anatomy, The London Hospital, E1 1BB London, UK |
| |
Abstract: | Summary Electron microscopy has been used to study the cell to cell and cell to stroma contacts between smooth muscle cells (SMC) in normal vessels, angiomyolipoma and well and poorly differentiated vascular leiomyosarcoma. Micrographs were examined with a semiautomatic image analysis system. The length of the cell borders was calculated and the type and number of contacts per 100 µm cell perimeter and per 100 cells were determined. In all cases there was a predominance of simple appositions. Intermediate junctions, nexus junctions, interdigitations, intermediate contacts and junctional interdigitations were less frequently observed. In general, as the SMC become malignant and less differentiated the number of cell to stroma attachments decreases markedly and the intercellular contacts increase slightly. |
| |
Keywords: | Cell contacts Neoplastic vascular smooth muscle Human tumours |
本文献已被 SpringerLink 等数据库收录! |
|