年轻宫颈癌患者临床特点分析

目的分析年轻宫颈癌患者的临床病理特点及人乳头瘤病毒感染特点。方法回顾性分析河南省人民医院2008年1月—2009年12月57例≤35岁及239例〉35岁宫颈癌患者的临床病历资料,采用核酸分子快速杂交基因分型法进行HPVDNA分型检测或用HCII法进行高危型HPV测定。结果年轻宫颈癌组早期（≤Ⅱa期）病例53例（92.98%）,发生淋巴结转移10例（17.54%）,两组在临床分期、淋巴结转移率间差异有统计学意义（P〈0.05）,在病理分型、组织学分级、淋巴血管间隙浸润间差异无统计学意义（P〉0.05）。行HPV分型检测者研究组高危型HPV总感染率为80.77%（21/26）,高危型HPV亚型主要为16型（73.08%）,对照组高危型HPV总感染率为74.51%（76/102）,16亚型感染率为66.29%,行高危型HPV测定者研究组HPV阳性率为94.44%,对照组为83.33%,两组比较差异无统计学意义（P〉0.05）,两组高危型HPV感染种类及病毒载量间差异无统计学意义（P〉0.05）。结论年轻宫颈癌临床期别早、淋巴结转移率高,HPV感染率高,以16型多见。高危型HPV检测有助于宫颈癌的早期筛查。

Analysis of Characters of Cervical Carcinoma in Young Women

Objective To analyze the clinicopathology characteristics and HPV infection features in young women with cervical carcinoma.Methods The clinical informations of 57 patients under 35 years o1d with cervical carcinoma were retrospectively analyzed and compared to 239 patients over 35 years old from Jan.2008 to Dec.2009 in Henan Provincial People＇s Hospital.The infected types of human papillomavirus（HPV） were tested by rapid hybridization genotyping technique and the loads of high risk human papillomavirus（HR HPV） by HCII technique.Results There were 53 cases（92.98%） of early stage（≤Ⅱa stage） and 10 cases（17.54%） of lymph node metastasis（LNM） which were significantly higher than those in the control group（P0.05）.There were no significant differences between the two groups in pathologic type,histologic grade,lymph-vascular space invasion（LVSI）（P0.05）.High risk HPV prevalence of 26 cases tested for HPV specific type was 80.77%（21/26） in the study group vs 74.51%（76/102） in the control group,HPV16 was the most common type which accounted for 73.08% in the study group vs 66.29% in the control group.Positive rates of High risk HPV tested for HPV loads were 94.44% and 83.33% respectively.There was no significant difference between the two groups.No significant differences of amounts of infected HR HPV varieties and virus loads were found between the two groups.Conclusion The younger patients with cervical carcinoma were characterized by higher rates of early stage,lymph node metastasis and HPV infection.HPV 16 was the most common type.Testing of High risk HPV will help to the scanning of cervical carcinoma.