| FOLFOX4方案治疗晚期食管癌疗效观察 |
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| 引用本文： | 路太英,王新华,李文斌,王留兴,王瑞林,樊青霞.FOLFOX4方案治疗晚期食管癌疗效观察[J].河南医药信息,2010(16):59-60. |
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| 作者姓名： | 路太英 王新华 李文斌 王留兴 王瑞林 樊青霞 |
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| 作者单位： | 郑州大学第一附属医院肿瘤科,郑州市450052 |
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| 摘 要： | 目的观察FOLFOX4方案治疗晚期食管癌的疗效及不良反应。方法按FOLFOX4方案,奥沙利铂85mg/m2,静脉滴注,第1d;CF200mg/m2,静脉滴注,第1,2d;5-FU400mg/m2静脉推注,5-FU600mg/m2持续泵入22h,第1,2d;每2周重复。结果可评价疗效者42例,总有效率52.4%,其中CR1例（2.4%）,PR21例（50.0%）,SD11例（26.2%）,PD9例（21.4%）,临床获益率78.6%。中位TTP5.6个月,1年生存率45.2%。不良反应较轻,无化疗相关死亡。结论 FOLFOX4方案治疗晚期食管癌临床疗效较好,不良反应可以耐受。
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| 关 键 词： | 食管肿瘤 化疗 奥沙利铂 亚叶酸钙 5-氟尿嘧啶 |
Clinical Observation of FOLFOX4 in Treatment of Advanced Esophageal Cancer |
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| Institution: | LU Taiying,WANG Xinhua,LI Wenbing,et al Department of Oncology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China |
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| Abstract: | Objective To observe the efficiency and toxicity of the chemotherapy regimen FOLFOX4 for the patient with advanced esophageal cancer.Methods All advanced esophageal cancer received FOLFOX4 regimen,Oxaliplatin 85mg/m2iv.day 1,CF 200 mg/m2iv.day 1 and 2,5-FU 400 mg/m2 iv.bolus,then 600mg/m2 iv.over 22 hours continuous infusion,day 1 and 2,Repeat every 2weeks.Results Totally 42 patients with advanced esophageal cancerentered the study.Major objective responses rate was 52.4%,including 1case complete response,21 cases partial response,11 cases stable disease and 9 cases progressive disease.Clinicle benifiterate was78.6%.Themedian time to progressive was 5.6 months,1 year survival rate was 45.2%.Conclusion FOLFOX4 regimen show good efficacyand an acceptable toxicity in treatment of advanced esophageal cancer. |
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| Keywords: | Esophageal cancer Chemotherapy Oxaliplatin Leucovorin 5-fluorouracil |
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