| 异种移植中的移植物抗宿主病 |
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| 引用本文： | 王坤杰,李幼平,杨宇如.异种移植中的移植物抗宿主病[J].中国修复重建外科杂志,2000,14(3):181-185. |
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| 作者姓名： | 王坤杰 李幼平 杨宇如 |
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| 作者单位： | 1. 华西医科大学附属第一医院泌尿外科,成都,610041
2. 移植工程与移植免疫实验室 |
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| 摘 要： | 目的 了解异种移植物抗宿主病（ＧＶＨＤ）的组织学特点，与同种ＧＶＨＤ的区别及异种脾脏移植的关系。方法 对近十年来有关异种移植中ＧＶＨＤ的特点及其与同种ＧＶＨＤ区别的文献进行检索、综述。结果异种ＧＶＨＤ由于共刺激信号、粘附分子的不匹配及所识别抗原的差异、其发生发展速度，组织学特点等均与同种ＧＶＨＤ不同。受体脾切除加异种脾移植有利于异种ＧＶＨＤ的发生。结论 可利用异种ＧＶＨＤ模型来观测异种移植排斥反应
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| 关 键 词： | 移植物抗宿主病 异种移植 脾脏移植 |
| 修稿时间： | 1999-07-20 |
XENOGENEIC GRAFT-VERSUS-HOST DISEASE |
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| WANG Kun-jie,LI You-ping,YANG Yu-ru.XENOGENEIC GRAFT-VERSUS-HOST DISEASE[J].Chinese Journal of Reparative and Reconstructive Surgery,2000,14(3):181-185. |
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| Authors: | WANG Kun-jie LI You-ping YANG Yu-ru |
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| Institution: | Department of Urinary Surgery, First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan, P. R. China 610041. |
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| Abstract: | OBJECTIVE: To evaluate the histological characteristics of xenogeneic graft-versus-host disease (GVHD), and to differentiate it from the allogeneic GVHD. METHODS: The original articles related to the characteristics of xenogeneic GVHD and the relationship between xenogeneic GVHD and allogeneic GVHD were widely reviewed in the past decade. RESULTS: Xenogeneic GVHD was different from allogeneic GVHD in the speed of development, position and features of pathological changes, due to the incompatibility of common simulative signals, adhesive molecules and difference of antigens. Xenogeneic spleen transplantation could induce xenogeneic GVHD. CONCLUSION: Xenogeneic GVHD can be used as a model to mimic rejection in xenotransplantation and to evaluate the compatibility of xenotransplantation. |
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| Keywords: | Graft versus host disease Swine to human Xenotransplantation Spleen |
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