恶性组织细胞增生症瘤细胞来源的探讨

恶性组织细胞增生症（简称恶组）一直被列入人体的组织细胞（单核吞噬细胞系统）来源的高度恶性肿瘤的范畴．自1985年以来，陆续有国外文献报道恶组的瘤细胞表达T淋巴细胞的标记，因而将恶组列入了T细胞淋巴癌的范畴，但仍有一些文献并未同意这种新见解。结合癌细胞的组织形态表现，我们发现，表达两种标记者常示瘤细胞分化较好吞噬现象明显；仅表达一种者，瘤细胞分化中等；两者均不表达者示瘤细胞分化差，几乎见不到吞噬现象。对此认识．仍有待进一步的探入探讨。

MALIGNANT HISTIOCYTOSIS:INVESTIGATION ON PHENOTYPE

Recently, some doubt has been cast on the actual histiocytic nature of the malignant cell in mailgnant histiocytosis(MH). Meanwhile, the demonstration of T cell gene rearrangement in MH has been reported. 46 cases of MH were evaluated for clinical and histopathologic features and phenotype.The neoplastic cells involved predominantly lymph modes, liver, spleen, bone marrow, lung, digestive tract, kidney etc,. In 21 cases of this group, 10 cases exhibited UCHLi and AACT+, 3 cases UCHL1 and ACCT , 3 cases UCNL1 and AACT and 5 cases UCHL1 and AACT ,The cell which showed positive markers of UCHL1 and AACT were well differentiates and the cells which showed neg- ative markers of UCHL1 and AACT were poorly differentiated histologically. This phenotypic results suggested that the primary stem cells of hemopoesis could be the origin cell of MH.