Malignant prolactinoma. |
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| Authors: | M Berezin I Gutman R Tadmor A Horowitz G Findler |
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| Affiliation: | Institute of Endocrinology, Chaim Sheba Medical Center, Tel Hashomer, Israel. |
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| Abstract: | Malignant prolactinoma is a rare entity and only a few cases have been published. The diagnostic criteria and the clinical course remain unclear. We present a case of malignant prolactinoma in a woman with a 30-year duration of the disease. In the terminal stage of the disease the prolactinoma metastasized to the left eye, the prolactin level reaching 196000 mU/l. Bromocriptine in high doses was not effective. The response to pergolide was good in the first two years of treatment; thereafter an escape effect was observed. The patient died in a comatose state. A review of previously published cases follows. |
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