| 2型糖尿病患者尿nephrin排泄量的变化及其临床意义 |
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| 引用本文： | 赵俐丽,叶山东,陈燕,范爱红. 2型糖尿病患者尿nephrin排泄量的变化及其临床意义[J]. 中国临床保健杂志, 2009, 12(3): 253-255 |
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| 作者姓名： | 赵俐丽 叶山东 陈燕 范爱红 |
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| 作者单位： | 安徽医科大学附属省立医院、安徽省立医院内分泌科,合肥,230001;安徽医科大学附属省立医院、安徽省立医院内分泌科,合肥,230001;安徽医科大学附属省立医院、安徽省立医院内分泌科,合肥,230001;安徽医科大学附属省立医院、安徽省立医院内分泌科,合肥,230001 |
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| 摘 要： | 目的探讨2型糖尿病患者尿nephrin排泄量的变化及其与尿白蛋白排泄量的关系。方法87例2型糖尿病患者根据尿白蛋白、肌酐比值分为:正常白蛋白尿组,微量白蛋白尿组,临床白蛋白尿组。检测所有入选者尿nephrin(酶联免疫吸附法)及其相关因素。结果健康对照组患者尿中未检测到nephrin排泄,糖尿病组尿液中可检测到nephrin。正常白蛋白尿患者可检测到微量nephrin排泄,大量白蛋白患者尿nephrin/尿肌酐比值显著高于微量白蛋白尿组(P<0.01),尿nephrin/尿肌酐比值与尿白蛋白/尿肌酐呈显著性正相关。结论2型糖尿病患者尿nephrin排泄增加,并与糖尿病肾病的病情程度有关。
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| 关 键 词： | 糖尿病肾病 白蛋白尿 酶联免疫吸附法 |
Change and its clinical significance of urinary nephrin excretion in type 2 diabetics |
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| ZHAO Li-li,YE Shan-dong,CHEN Yan,FAN Ai-hong. Change and its clinical significance of urinary nephrin excretion in type 2 diabetics[J]. Chinese Journal of Clinical Healthcare, 2009, 12(3): 253-255 |
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| Authors: | ZHAO Li-li YE Shan-dong CHEN Yan FAN Ai-hong |
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| Affiliation: | Department of Endocrinology;Anhui Procincial Hospital;Hefei 230001 |
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| Abstract: | Objective To observe the change of the urinary nephrin excretion and its relationship with albuminuria in type 2 diabetics.Methods 87 diabetics were divided into normal albuminuria group,micro-albuminuria group and macro-albuminuria group.Urinary nephrin were measured by enzyme-linked immunosorbent assay.Results Urinary nephrin didn't be detected in normal control group,but its excretion was found increased in the urine of diabetics.The urinary nephrin/ urinary creatinine ratio in macro-albuminuria group wa... |
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| Keywords: | Diabetic nephmpathies Albuminuria Enzyme-linked immunosorbent assay |
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