| 肿瘤放疗增敏药9401号的细胞毒性和体外放射增敏作用 |
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| 引用本文： | 顾菲,刘晓秋,韩英,赵艳芝,胡晓林,宋汝亮.肿瘤放疗增敏药9401号的细胞毒性和体外放射增敏作用[J].中国辐射卫生,2006,15(4):392-393. |
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| 作者姓名： | 顾菲 刘晓秋 韩英 赵艳芝 胡晓林 宋汝亮 |
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| 作者单位： | 中国医学科学院放射医学研究所,天津,300192 |
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| 基金项目： | 天津市自然科学基金资助(No.043610411) |
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| 摘 要： | 目的观察新的肿瘤放疗增敏药9401号对离体Hela细胞的细胞毒性和体外放射增敏作用。方法采用细胞克隆形成法研究9401号的细胞毒性和放射增敏作用。结果9401号对Hela细胞有较强的细胞毒性,随着药物浓度增加而增加,半数抑制剂量(ID50)为4.65 mg/ml。用3 mg/ml的9401号药作用于Hela细胞3,6,12和24 h后,各组均可见放射增敏效应,相应的放射增敏比SERDO分别为1.33,1.5,1.63和1.67;SERDq分别为1.38,1.89,2.47和3.33;SERSF2分别为1.32,1.82,2.41和3.02。结论9401号对Hela细胞的细胞毒性呈剂量依赖性关系。放射增敏作用明显,随药物作用时间延长而增强。
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| 关 键 词： | 放射增敏 9401号 Hela细胞 |
| 文章编号： | 1004-714X(2006)04-0392-02 |
| 收稿时间： | 2006-03-07 |
| 修稿时间： | 2006年3月7日 |
Cytotoxicity and radiosensititizing effect of 9401 in vitro |
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| GU Fei, LIU Xiao Qiu, HAN Ying, et al.Cytotoxicity and radiosensititizing effect of 9401 in vitro[J].Chinese Journal of Radiological Health,2006,15(4):392-393. |
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| Authors: | GU Fei LIU Xiao Qiu HAN Ying |
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| Institution: | Instinute of Radiation Medicine,Chinese Academy of Medical Sciences,Peking Union Medical College,Tianjin 300192 China |
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| Abstract: | Objective To investigate the cytotoxicity and radiosensitization of 9401 on Hela cells. Methods The cytotoxicity and radiosensitization of 9401 were investigated by using clongenic assay on Hela cells in vitro.Results The cytotoxicity of 9401 was in a dose-dependent manner.The 50% inhibition concentration of 9401 was 4.65?mg/ml.With 3?mg/ml 9401 exposed to Hela cells for 3,6,12 and 24 hours,the corresponding SERDO was 1.33,1.5,1.63 and 1.67;SER_(Dq) was 1.38,1.89,2.47 and 3.33;SERSF2 was 1.32,1.82,2.41 and 3.02.Conclusion The cytotoxicity of 9401 was in a dose-dependent manner.9401 has a radiosensititizing effect,and the radiosensitization is dependent on time. |
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| Keywords: | Radiosensititizing 9401 Hela Cells |
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