聚乙烯醇-胶原创伤敷料的研制

研制一种新型的聚乙烯醇-胶原复合材料,探讨其作为创伤敷料的可行性.聚乙烯醇(PVA)与I型胶原以3:1比例混合,以聚乙二醇为制孔剂,风干成为膜状,并对其进行抗张强度、孔径与孔隙率、吸水率检测及细胞生物相容性评价试验.结果显示:PVA-胶原膜的抗张强度为8.10±0.28 MPa;平均孔径为100～150 μm,孔隙率90%左右;吸水率为185.42%±6.93%;3T3细胞在PVA-胶原膜上生长形态正常,增殖迅速.因此,PVA-胶原膜具有较理想的力学强度、孔径与孔隙率以及良好的细胞相容性,可进一步探讨其作为创伤敷料的体内应用.

Study of the Polyvinyl Alcohol-Collagen Blend as Wound Dressing

This study sought to explore a new compound polyvinyl alcohol-collagen as a wound dressing. To make the polymer, Polyvinyl alcohol (PVA) and collagen type I were put together in the ratio of 3:1, at the same time, polyethlene glycol as porogen was added, and the material was dried by air to be a membrane in shape. Then the ultimate tensile load, the hole diameter, porosity, and water absorption were measured. The cell biocompatibility was tested as well. The results showed the PVA-collagen blend had the average hole 100-150 microm in diameter, and the porosity about 90%. The ultimate tensile load reached 8.10 +/- 0.28 MPa, and water absorption was up to 185.42% +/- 6.93%. 3T3 cells grew well on the PVA-collagen member. Therefore, the PVA-collagen memberane is characterized not only by its ideal biomechanical ability and biocompability, but also by its ideal hole diameter, porosity and water absorption. It may have the potential for use as a wound dressing in vivo.