Anti-inflammatory activity of imipramine and congeners |
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| Authors: | K K Tangri P R Saxena P K Seth K P Bhargava |
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| Affiliation: | 1. BC Mental Health and Addictions Research Institute, 938 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada;2. Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 2A1, Canada;3. Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan;4. Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada;5. Department of Psychiatry, University Medicine Goettingen, von-Siebold-Strasse 5, D-37075 Goettingen, Germany;6. Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, D-80336 Munich, Germany;7. Rush Alzheimer''s disease Center, Rush University Medical Center, 600 S. Paulina Street, Chicago, IL 60612, United States |
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| Abstract: | Imipramine was found to possess potent anti-inflammatory property similar to hydrocortisone on formalin-induced arthritis in albino rats. Desmethyl imipramine and amitriptyline, the two congeners of imipramine, were devoid of such an activity.Imipramine was shown to give significant protection against 5-HT and histamine aerosol-induced bronchospasm in guinea pigs, although it was a weaker antagonist of 5-HT and histamine than BOL-148 and mepyramine, respectively.Imipramine, like hydrocortisone, prevented the elevation of S-GOT and S-GPT levels during inflammation. It reduced the S-GPT but not the S-GOT level in normal rats. ATPase activity was significantly increased by imipramine in liver and brain homogenates during the inflammatory state although inflammation did not alter the ATPase activity in tissue homogenates. |
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