血红素氧合酶-1与冠心病

血红素氧合酶能将血红素催化降解成具有不同生物活性的铁、一氧化碳及胆红素。胆红素是机体内清除过氧化脂质和超氧自由基的重要生理抗氧化物质，能抗缺血／再灌注损伤，胆红素的含量与冠心病的发病率呈负相关。一氧化碳是一种新的信使因子，通过激活可溶性鸟苷酸环化酶(sGC)，舒张血管平滑肌，抑制血小板聚集和抑制血管平滑肌细胞(VSMCs)增殖，从而恢复冠状动脉的正常血流。血红素氧合酶通过其抗动脉粥样硬化作用对冠状动脉起保护作用。

Hemeoxygenase-1 and coronary artery disease

Heme oxygenase (HO) catalyzes the degradation of heme to carbon monoxide(CO),iron and bilirubin.These products of the HO reaction have important physiological effects:Bilirubin is important to prevent lipid from oxidation,to clean oxygen-derived free radicals from the body,and to guard against ischemia/reperfusion injury,whose content in blood has a negative correlation with the incidence rate of coronary artery disease(CAD).As a new messenger factor,carbon monoxide can activate soluble guanyl cyclas(sGC),relax angio-smooth muscle,prevent platelet from aggregation and inhibit angio-smooth muscle cells proliferation,therefore it can maintain normal blood stream in coronary artery.Heme oxygenase protects coronary artery by the way of anti-atherosclerosis.