| 系统性红斑狼疮与人类白细胞抗原-Cw基因相关性的研究 |
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| 引用本文： | 孙红胜,侯岩峰,张源潮,焦玉莲,杨清锐,孙广智,赵跃然.系统性红斑狼疮与人类白细胞抗原-Cw基因相关性的研究[J].中华风湿病学杂志,2008,12(10). |
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| 作者姓名： | 孙红胜 侯岩峰 张源潮 焦玉莲 杨清锐 孙广智 赵跃然 |
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| 作者单位： | 1. 山东大学附属省立医院风湿免疫科,济南,250021
2. 济南市第四人民医院骨外科 |
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| 基金项目： | 国家自然科学基金，山东省科技发展基金 |
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| 摘 要： | 目的 探讨系统性红斑狼疮(SLE)与人类白细胞抗原(HLA)-Cw等位基因的相关性.方法 应用聚合酶链反应-序列特异性引物(PCR-SSP)的方法对108例SLE患者和102名健康人HLA-Cw01-08等位基因进行检测,比较两组间各等位基因的基因表型频率分布差异.结果 SLE患者组中HLA-Cw07的基因表型频率高于对照组,差异有统计学意义.结论 HLA-Cw07可能是SLE的易感基因或易感连锁基因.
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| 关 键 词： | 红斑狼疮 系统性 HLA抗原 等位基因 |
Association of HLA-Cw alleles with systemic lupus erythematosus |
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| SUN Hong-sheng,HOU Yan-feng,ZHANG Yuan-chao,JIAO Yu-lian,YANG Qing-rui,SUN Guang-zhi,ZHAO Yue-ran.Association of HLA-Cw alleles with systemic lupus erythematosus[J].Chinese Journal of Rheumatology,2008,12(10). |
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| Authors: | SUN Hong-sheng HOU Yan-feng ZHANG Yuan-chao JIAO Yu-lian YANG Qing-rui SUN Guang-zhi ZHAO Yue-ran |
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| Abstract: | Objective To explore the association between HLA-Cw alleles with systemic lupuserythematosus. Methods Polymerase chain reaction-sequence specific primer method was used to analyze thedistribution of HLA-Cw01-08 alleles among 108 patients with SLE and 102 healthy controls. The allelefrequencies was compared between various patient groups and the control population. Results The frequencyof HLA-Cw07 alleles in patients with SLE was significantly increased in patients with SLE. Conclusion Theresults indicate that HLA-Cw07 may be the susceptible alleles or may be closely linked to the susceptiblegenes for SLE. |
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| Keywords: | Lupus erythematesus systemic HLA antigens Alleles |
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