门静脉癌栓消融新方法的实验研究

目的探讨门脉癌栓有效的介入治疗方法，降低肝癌切除术后及肝移植术后的复发率。方法在超声引导下将VX2癌细胞注入新西兰大白兔门静脉内，形成门脉癌栓。门脉癌栓动物模型建立后，在超声引导下穿刺门静脉置入7FPTCD管，从PTCD管内置入特制微波辐射电极进行消融。在消融同时经PTCD针注入化疗药氟尿嘧啶及顺铂。通过超声造影、CT增强扫描、病理判断疗效。结果消融术后超声扫描观察癌栓回声、超声造影及CT增强扫描较消融前增强，表明癌细胞已凋亡；消融前后肝功能异常率均达100％，但消融后ALT、AST比消融前明显下降；同时，消融对门脉壁及周围肝组织的损伤较轻。结论在超声引导下对门静脉内癌栓进行微波消融联合注入化疗药物可能是一种安全、有效的方法。

Portal vein tumor thrombus ablation of new method Experimental Study

Objective To Explore the effective interventional therapy for portal vein tumor thrombus, and to reduce the recurrence rate after liver resection or transplantation. Methods At ultrasound-guided VX2 cancer cells will be injected into New Zealand white rabbits with portal vein, portal vein tumor thrombus forma-tion. after the Animal model of portal vein tumor thrombus is set up. At ultrasound-guided portal vein puncture into 7 FVTCD tubes,inset the special microwave radiation ablation electrode from the PTCD tube, and ablation. At the same time by PTCD needle to inject the chemotherapy drugs fluorouracil and cisplatin. Through ultra-sonography, CT scan and pathology to determine the effect. Results After ablation, the thrombus echo of ultra-sound scan, contrast-enhanced ultrasound and CT scan is enhance than before ablation; It shows that cancer cells have apoptosis, the rate of abnormal liver function is both reached 100% before and after the ablation, However,the ALT, AST after ablation is decreased significantly than before ablation; At the same time,the por-tal vein wall and the surrounding liver tissue damage less. Conclusion At ultrasound-guided portal vein tumor thrombus within the microwave ablation United inject chemotherapy drugs probably is a safe, effective method.