MMP-8在妊娠期高血压疾病胎盘中的表达

目的 研究基质金属蛋白酶8-（MMP-8）在妊娠期高血压疾病胎盘中的表达，探讨MMP-8在妊娠期高血压疾病发病中的作用。方法 用免疫组化SABC法检测67例妊娠期高血压疾病患者及21例正常妊娠者胎盘组织中MMP-8的表达。结果 正常妊娠组胎盘MMP-8表达阳性率为80．9％，明显高于妊娠期高血压疾病组（26．9％）P〈0．05，随妊妊娠期高血压疾病病情的加重，MMP-8的表达有下降趋势。结论 妊娠期高血压疾病患者胎盘组织MMP-8的表达明显减少，且随其病情加重有下降趋势，表明MMP-8与妊娠期高血压疾病的发生有密切关系。

The expression of matrix metalloproteinases-8 in placenta of hypertensive disorder complicating pregnancy

Objective To investigate the expression of matrix metalloproteinases-8(MMP-8)in placenta of hypertensive disorder complicating pregnancy and approach its role in the course of hypertensive disorder complicating pregnancy.Methods MMP-8 of placenta was determined by immunohistochemical SABC assay and compared between 67 case hypertensive disorder complicating preg nancies and 21 case normal pregnancies.Results The positive rate of MMP-8 in normal pregnancies was 80.9%,which is significantly higher than that in hypertensive disorder complicating pregnancy(26.9%),P<0.05.Accompanying the aggravation of pathogenetic condition,the positive rate of MMP-8 in hypertensive disorder complicating pregnancy had a decreased tendency.Conclusion The expression of MMP-8 in hypertensive disorder complicating pregnancy decreased significantly and had a decreased tendency accompanying the aggravation of pathogenetic condition,which indicated that MMP-8 has a close relation with the development of hypertensive disorder complicating pregnancy.