氨茶碱和纳络酮联用治疗早产儿原发性呼吸暂停的效果

目的观察氨茶碱和纳络酮治疗早产儿原发性呼吸暂停的临床效果。方法100例患儿随机分为2组,治疗组50例在使用氨茶硷的基础上加用纳络酮,对照组50例单用氨茶硷。结果治疗组和对照组患儿的呼吸暂停次数分别为(1.8±0.2)、(3.4±1.2)次/d,治疗组明显减少(P0.01)。治疗组和对照组患儿的呼吸暂停时间分别为(18.9±3.1)、(23.2±2.51)s,治疗组明显缩短(P0.01);治疗组和对照组患儿呼吸暂停时SPO2下降程度及心率减慢程度分别为(83.0±8.4)%和(75.7±5.2)%,(95.3±12.8)和(86.6±13.5)次/min,(均P0.01。)治疗组总有效率92.6%,对照组总有效率68%(χ2=9.00,P0.01)。结论氨茶碱和纳络酮联合治疗早产儿原发性呼吸暂停比单用氨茶碱效果好,值得临床推广。

Effect of Aminophylline Combined with Naloxone in Treatment of Primary Apnea of Premature Infants

Objective ] To observe the clinical effect of aminophylline combined with naloxone in treatment of primary apnea of premature infants. Methods ] 100 cases were randomly divided into the treatment group （50 cases） and the control group （50 cases） , the treatment group was treated with naloxone on the basis of aminophylline therapy, and the control group received single aminophyl- line therapy. Results] The frequency of apnea in the treatment group and the control group were （ 1.8 ± 0.2） per day and （3.4 ± 1.2 ） per day respectively, and that in the treatment group decreased significantly （ P 〈 0.01 ）. The time of apnea in the treatment group and the control group were （ 18.9± 3.1 ） s and （23.2 ± 2.51 ） s respectively, and that in the treatment group shortened significantly （ P 〈 0.01）. The decreased degree of SPO2 and slowing degree of heart rate of apnea in the treatment group and the control group were （ 83.0 ± 8.4 ） % and （ 75.7 ± 5.2 ） % , （ 95.3 ± 12.8 ）/min and （ 86.6 ±13.5 ）/rain respectively, there were significant differences in them between two groups （ P 〈 0.01 ）. The total effective rate of the treatment group and the control group was 92.6% and 68 % （ χ^2= 9.00, P 〈 0.01 ）. Conclusion ] The clinical effect of aminophylline combined with naloxone in treatment of primary apnea of premature infants is better than that of single aminophylline therapy, and it is worth popularizing in clinic.