MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not |
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| Authors: | Langers A M J Sier C F M Hawinkels L J A C Kubben F J G M van Duijn W van der Reijden J J Lamers C B H W Hommes D W Verspaget H W |
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| Institution: | 1Department of Gastroenterology–Hepatology, Leiden University Medical Centre, Leiden, The Netherlands |
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| Abstract: | The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2(-1306T) and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP-9 levels were associated with poor prognosis but SNP MMP-9(-1562C>T) was not. Tumour MMP levels were not determined by their SNP genotypes. |
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| Keywords: | metalloproteinase SNP survival prognosis |
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