WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines |
| |
Authors: | Sung Jee Young Engmann Olivia Teylan Merilee A Nairn Angus C Greengard Paul Kim Yong |
| |
Affiliation: | *Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10065; and ;†Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508 |
| |
Abstract: | Mitochondrial fission and trafficking to dendritic protrusions have been implicated in dendritic spine development. Here, we show that Wiskott-Aldrich syndrome protein (WASP)-family verprolin homologous protein 1 (WAVE1) controls depolarization-induced mitochondrial movement into dendritic spines and filopodia and regulates spine morphogenesis. Depolarization-induced degradation of the p35 regulatory subunit of cyclin-dependent kinase 5 (Cdk5), with the resultant decreased inhibitory phosphorylation on WAVE1, depend on NMDA receptor activation. Thus, WAVE1 dephosphorylation and activation are likely associated with mitochondrial redistribution and spine morphogenesis. |
| |
Keywords: | Cdk5 filopodia depolarization phosphorylation NMDA receptor |
本文献已被 PubMed 等数据库收录! |
|