N末端B型钠尿肽原在慢性肾功能衰竭的应用价值

目的：探讨N末端B型钠尿肽原（NT-proBNP）测定在慢性肾功能衰竭疾病中的应用价值。方法：用电化学发光免疫法体外定量检测46例正常人和97例慢性肾功能衰竭患者血清NT-proBNP含量。结果：正常对照组血清NT-proBNP水平为（47.82±31.52）pg/ml;慢性肾功能衰竭患者的NT-proBNP值为（514.23±289.51）pg/ml,与血肌酐作相关性分析（r=0.380,n=97）;心功能异常的肾病患者与对照组比较,差异有统计学意义（P〈0.01）,而无心功异常的肾病患者与对照组比较差异无统计学意义（P〉0.05）;血透患者达到干体重组NT-proBNP与正常对照组比较差异无统计学意义,而未达到干体重组NT-proBNP与正常对照组的结果比较差异有统计学意义。结论：慢性肾功能衰竭患者BNP水平升高,心功能不全是主要影响因素;NT-proBNP测定在慢性肾功能衰竭疾病中具有筛查心功能不全患者、评价血透患者干体重及评价预后和疗效等临床应用价值。

Clinical value of N-terminal pro-B type natriutetic peptide(NT-p roBNP)in chronic renal failure

Objective： To investigate the clinical value of N-terminal pro-B type natriutetic peptide（NT-p roBNP） in chronic renal failure.Methods： The levels of serum NT-proBNP in healthy people（n=46） and chronic renal failure people（n=97） were measured by electro-chemiluminescent immunoassay.Results： The mean concentrations of NT-proBNP were（47.82±31.5） pg/ml in healthy people and（514.23±289.51） pg/ml in chronic renal failure people.Ee made correlation between NT-proBNP and Cr（r=0.380,n=97）;NT-proBNP in renal patients with heart disease were significantly different with controls（P0.01）,but patients with no heart disease were not,there was no significant difference（P0.05）;Similarly,NT-proBNP in hemodialysis with lower dry weight were significantly different with controls,but higher dry weight not.Conclusion： The main reason of NT-proBNP increasing in chronic renal failure people is heart failure.So we can find heart failure,investigate the dry weight of hemodialysis and the clinical value by measuring NT-proBNP of chronic renal failure people.