西酞普兰与阿普唑仑治疗广泛性焦虑症对照研究

目的：探讨西酞普兰治疗广泛性焦虑症的临床疗效。方法：将66例广泛性焦虑症患者随机分为两组,西酞普兰组34例,阿普唑仑组32例。西酞普兰组治疗剂量40～60 mg/d,阿普唑仑组为2.4～3.6 mg/d,观察时间均为6周。治疗前与治疗第1、2、4、6周末采用HAMA、SAS、TESS评定临床疗效和副反应。结果：两组疗效相当,差异无统计学意义（P〉0.05）;阿普唑仑组起效时间快,但远期疗效差于西酞普兰组;西酞普兰组副反应明显少于阿普唑仑组（P〈0.05）。结论：西酞普兰治疗广泛性焦虑疗效肯定,依从性好。

Control study of citalopram and alprazolam in treatment of generalized anxiety disorder

Objective： To investigate the clinical effects of citalopram in the treatment of generalized anxiety disorder.Methods： 66 patients with generalized anxiety disorder were randomly divided into two groups,with 34 patients for the citalopram group and 32 patients for the alprazolam group.The therapeutic dose was 40-60 mg/d for the citalopram group and 2.4-3.6 mg/d for the alprazolam group.The observation time was 6 weeks for both groups.The clinical effects and side effects before and 1,2,4,6 weeks after treatment were assessed using HAMA,SAS and TESS.Results： Clinical effects of the two groups were similar,with no significant difference（P0.05）.The alprazolam group had faster action but much worse long-term effects than the citalopram group.The citalopram group had significantly less side effects than the alprazolam group（P0.05）.Conclusion： Citalopram has good clinical effects and compliance in the treatment of generalized anxiety disorder.