| 芍药甙的药代动力学研究 |
| |
| 引用本文： | 陈崇宏,张源,陈光亮,李俊,赵维中,张运芳,徐叔云.芍药甙的药代动力学研究[J].中国药理学通报,1990(5). |
| |
| 作者姓名： | 陈崇宏 张源 陈光亮 李俊 赵维中 张运芳 徐叔云 |
| |
| 作者单位： | 安徽医科大学临床药理研究所，安徽医科大学临床药理研究所，安徽医科大学临床药理研究所，安徽医科大学临床药理研究所，安徽医科大学临床药理研究所，安徽医科大学临床药理研究所，安徽医科大学临床药理研究所 合肥 230032，合肥 230032，合肥 230032，合肥 230032，合肥 230032，合肥 230032，合肥 230032 |
| |
| 摘 要： | 芍药是白芍的主要成份,狗iv芍药甙11.25mg/kg后,血药浓度曲线符合二室模型。动力学参数:T_(1/2)(α)为6.29±1.80min,T_(1/2)(β)为133.41±84.89min,VB为0.54±0.10L/kg,CL为3.41±1.01ml/kg·min~(-1)。本品静注后迅速以原型出现于尿中,前20min和7h尿中累积排泄量占静注量分别为36.85%和79.33%,7h胆汁中累积排泄量占静注量为3.77%
|
| 关 键 词： | 芍药甙 高效液相色谱法 药代动力学 |
THE STUDIES ON PHARMACOKINETICS OF PAEONIFLORIN |
| |
| Chen Chonghong,Zhang Yuan,Chen Guangliang,Li Jun et al.THE STUDIES ON PHARMACOKINETICS OF PAEONIFLORIN[J].Chinese Pharmacological Bulletin,1990(5). |
| |
| Authors: | Chen Chonghong Zhang Yuan Chen Guangliang Li Jun |
| |
| Abstract: | We first report the pharmacokinetics of paeoniflorin ( PF), that is a main component of paeony roots, in dogs by HPLC analysis. The experimental results were shown that after i .v . of 11.25 mg/kg PF in 4 dogs, the curve of plasma concentrations versus times for PF was fitted well to a open 2 compartment model, the T1/2 (α) was 6.29±
1.80min T1/2 ( β ) was 133.41±84.89 min, VB was 0.54 ± 0.10 L/kg, and
CL was 3.41 ± 1.01ml/min·kg-1 .
The results also were shown that PF was rapidly removed from the blood by kidney and the accumulated recovery amounts of excretion was 36.85% and 79.33% of total i .v . doses during 20 min and 7h administrations respectively. The elimination of PF by liver was lower than by kidney, and the accumulated amount of PF in bile was only 3.77% within 7h after iv. |
| |
| Keywords: | Paeoniflorin HPLC Pharmacokinetics |
| 本文献已被 CNKI 等数据库收录！ |
|
