诺维本联合顺铂治疗阿霉素类药物耐药性的晚期乳腺癌的疗效

目的：观察诺维本(Navelbine，NVB)联合顺铂(DDP)治疗阿霉素耐药性的晚期乳腺癌疗效及毒副反应。方法：对36例乳腺癌术后复发转移者，且全部为阿霉素治疗后转移或复发的晚期乳腺癌患者。NVB 25mg／m^2。静脉滴人。d1、d8；DDP30mg／m^2静脉滴入。第d1～d3。21天为1周期，全组化疗共90周期，中位数2．5周期(2～4周期)。结果：36例患者中有效率为61．1％(22／36)，CR4例，PR18例，SD10例。PD4例。主要毒性为骨髓抑制。以白细胞减少为主。其发生率为88．9％。本组绝大多数经锁骨下静脉置管给药，故静脉炎的发生率很低，其他毒性轻微。结论：NVB DDP治疗阿霉素类药物耐药性的晚期乳腺癌疗效较好，且毒性可以耐受，值得临床推广应用。

Effect of navelbine(NVB) combined with cisplatin(DDP) in treatment of adriamycin(ADM) resistant advanced breast carcinoma patients

Objective To observe the therapeutic effects of NVB combined with DDP in the treatment of ADM-resistant advanced cases of breast cancers.Methods 36 cases of advanced breast cancers had been treated with ADM with recurrence and/or metastases were studied. The treatment consisted of NVB 25 mg/m2 i.v. on day 1 and day 8; DDP 30 mg/m2 i.v. from day 1 to day 3; 21 days a cycle. Altogether 90 cycles were given with a median of 2.5 cycles(2-4 cycles). Results Among the 36 cases, there were CR 4 cases, RP 18 cases,SD 10 cases and PD 4 cases. The all over response rate was 61.1%(27/36). The main toxic effects were bone marrow suppression,mainly leukopenia in 88.9%.The incidence of phlebitis was very low, since in most cases drugs were given through subclavicle vein intubation. Conclusion For ADM-resistant advanced cases of breast cancer, NVB combined with DDP is an effecfive method of treatment and the toxic effect are tolerable.