| 类风湿关节炎的骨组织计量学研究 |
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| 引用本文： | 李锋,党耕町,冯传汉,吕厚山.类风湿关节炎的骨组织计量学研究[J].北京大学学报(医学版),1991(6). |
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| 作者姓名： | 李锋 党耕町 冯传汉 吕厚山 |
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| 作者单位： | 北京医科大学人民医院骨关节病中心，北医大第三医院骨科，北京医科大学人民医院骨关节病中心，北京医科大学人民医院骨关节病中心 |
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| 摘 要： | 用不脱钙骨切片经骨组织计量学方法,研究了类风湿关节炎(RA)膝关节骨组织的改变。结果表明:RA患者的松质骨体积(TBV),平均骨壁厚度(MWT)值明显低于对照组。骨小梁成骨细胞表面(TOBI.S)、骨小梁破骨表面(TORS)值明显高于对照组,其他测量指标变化不明显。这提示:在RA患者近关节骨组织骨转换率增高和骨重建单位的负平衡是导致RA骨质疏松的主要因素。用Masson’s染色,显微镜观察到骨小梁矿化骨中间出现较多的类骨样组织和编织骨,在紧贴软骨下区大量浆细胞聚积,也可见较多的肥大细胞。
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| 关 键 词： | 骨质疏松 类风湿关节炎 骨组织计量学 |
HISTOMORPHOMETRICAL OBSERVATION ON KNEE JOINT TISSUE OF RHEUMATOID ARTHRITIS |
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| Abstract: | Changes in bone tissue from RA knee joint were studied histomorphometricly. Tho results demen-
strated both TBV and MWT were evidently less than the control, while TOBI.S as well as TORS were
obviously higher.
Other parameters measured showed no evident changes. It was revealed that in RA the bone turn-
over rate was increased and bone remodeling was in negative balance. It is suggested that the above
two factors jointly lead to the osteoporosis in RA. |
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| Keywords: | Osteoporosis Rheumatoid arthritis(RA) Histomorphometry |
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