替硝唑预防和治疗干槽症的临床观察

目的：评价替硝唑预防和治疗干槽症的疗效及其安全性。方法：收集1998年12月至2000年12月在我科防治的1200例患者，分别用替硝唑（Tinidazole）预防智齿拔除术后干槽症600例（为试验组）和甲硝唑（Metronidazole）预防术后干槽症600例（为对照组）；并用替硝唑治疗术后干槽症14例（为试验组）；用甲硝唑治疗术后干槽症14例（为对照组）。通过对临床疗效观察和实验室检查，以评价其疗效和安全性。对厌氧菌培养阳性的标本进行了替硝唑和甲硝唑的最小抑菌浓度测定。结果：替硝唑在防治干槽症的疗效明显优于甲硝唑，其不良反应也轻微。结论：替硝唑是一种高效、安全的抗厌氧菌新药，可替代甲硝唑。

Analgesic effects of tinidazole in the prevention and treatment of alveolalgia

Objectives:To evaluate the analgesic effects and safety of tinidazole in the prevention and treatment of alveolalgia. Methods:Tinidazole was used in 600 patients after the extraction of impacted tooth as the test group for the prevention of alveolalgia, and metronidazole was used in other 600 patients as the control group. The clinical and laboratory tests were carried out before and after the treatment. And the MIC of tinidazole and metronidazole were determined in samples of positive anaerobic cultures. Results:Twenty eight patients with alveolalgia were treated. It showed that it was significantly more effective in the test group than that in the control group. The MIC of the tinidazole group, however, was not different from that of the metronidazole group( P >0.05).There was also little side effects from the use of tinidazole. Conclusions:Tinidazole is an effective and safe antianaerobic medicine and can be used to replace metronidazole.