| 抗中性粒细胞胞浆抗体对溃疡性结肠炎诊断价值的研究 |
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| 引用本文： | 郑艳,毕胜利,李忠廉. 抗中性粒细胞胞浆抗体对溃疡性结肠炎诊断价值的研究[J]. 中国实验诊断学, 2000, 4(5): 213-214 |
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| 作者姓名： | 郑艳 毕胜利 李忠廉 |
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| 作者单位： | 1. 吉林市肿瘤研究所,吉林,132001
2. 北华大学生物医学研究所 |
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| 基金项目： | 本课题受吉林省卫生厅资助(940444) |
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| 摘 要： | 目的 建立固定中性粒细胞－ＥＬＩＳＡ，分析血清中抗中性粒细胞胞浆抗体（ＡＮＣＡ）对溃性结肠炎（ＵＣ）的诊断价值。方法 采用固定中性粒细胞－ＥＬＩＳＡ法检测２５份ＵＣ血清、２６份细菌性结肠炎血清、１５份混合类型腹泻血清和５０份正常对照血清中的ＡＮＣＡ，对各组血清的吸光度（Ａ）值进行统计分析。结果 ＵＣ组ＡＮＣＡ与其他对照组ＡＮＣＡ之间的差异非常显著（Ｐ〈０．００５）。ＵＣ组Ａ值超过正常对照组Ａ值２ｓ
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| 关 键 词： | 溃疡性结肠炎 抗中性粒细胞胞浆抗体 FN－ELISA |
| 文章编号： | 1007-4287(2000)10-0213-02 |
| 修稿时间： | 2000-06-05 |
Clinical Evaluation of ANCA in Sera of the Patients with UC |
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| ZHENG Yan,BI Sheng-Li,LI Zhong-Lian. Clinical Evaluation of ANCA in Sera of the Patients with UC[J]. Chinese Journal of Laboratory Diagnosis, 2000, 4(5): 213-214 |
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| Authors: | ZHENG Yan BI Sheng-Li LI Zhong-Lian |
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| Abstract: | Objective The clinical evaluation of anti-Nutrophil cytoplasmic antibodies (ANCA) in sera of the patients with Ulcerative Colitis (UC). Methods The ANCA in sera from 25 patients with UC, 26 with Bacterial COlitis, 15 with Miscella- neons diarrheal illness and 50 normal subjects were detected with Fixed NeutroPhil Enzyme linked Immunosorbent Assay. Results The ANCA levels in sera of UC were obviously higher than those in other controls (P<0.005), 80% Of sera ANCA from UC had absorbance (A) beyond the values of normal subjects being plused 2s, the diagnostic specificity was 89%. Conclusion The results showed prescence of ANCA in sera with UC and this assay may be a valuble test for clinical diagnosis of UC. |
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| Keywords: | Ulcerative Colitis Anti-Nutrophil Cytoplasmic Antibodies Fixed Neutrophil Enzyme linked Immunosorbent Assay |
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