| HP和细胞凋亡在胃粘膜病变中作用关系的研究 |
| |
| 引用本文： | 汤建华,吕农华,晏楠,谢勇,陈江,徐萍,王崇文. HP和细胞凋亡在胃粘膜病变中作用关系的研究[J]. 江西医学院学报, 2000, 40(1): 29-31 |
| |
| 作者姓名： | 汤建华 吕农华 晏楠 谢勇 陈江 徐萍 王崇文 |
| |
| 作者单位： | 江西医学院第一附属医院消化内科，江西南昌330006 |
| |
| 基金项目： | 国家自然科学基金!资助项目 (396 6 0 0 78)，江西省自然科学基金!资助项目 (9740 6 5 ) |
| |
| 摘 要： | 为探讨HP感染和细胞凋亡在胃粘膜病变中作用，用TUNE1法检测了136例胃粘膜病变患者的胃粘膜细胞凋亡情况，结果发现，胃癌细胞凋亡减少：HP（＋）者细胞凋亡较HP（－）者明显增加，HP根除以后细胞凋亡有显著下降。这表明HP可以诱导胃细胞凋亡，细胞凋亡受抑制可能是胃癌发病机制之一，根除HP以减少细胞凋亡可能有助于预防胃粘膜病变的发生。
|
| 关 键 词： | 幽门螺杆菌 细胞凋亡 癌前状态 胃肿瘤 病因学 |
| 修稿时间： | 1999-12-02 |
A Study on the Interaction between Helicobacter Pylori and Apoptosis in Gastric Mucosal Lesions |
| |
| TANG Jian-hua,L Rong-hua,YIAN Nan,XIE Yong,CHEN Jiang,XU Ping,WANG Chong-wen. A Study on the Interaction between Helicobacter Pylori and Apoptosis in Gastric Mucosal Lesions[J]. Acta Academiae Medicinae Jiangxi, 2000, 40(1): 29-31 |
| |
| Authors: | TANG Jian-hua L Rong-hua YIAN Nan XIE Yong CHEN Jiang XU Ping WANG Chong-wen |
| |
| Affiliation: | TANG Jian-hua,L(U) Rong-hua,YIAN Nan,XIE Yong,CHEN Jiang,XU Ping,WANG Chong-wen |
| |
| Abstract: | To study the interaction between helicobacter pylori (HP) and apoptosis in gastric mucosal lesions,136 cases with gastric mucosal lesions have been detected by TUNEl.The results indicated:Apoptosis in gastric cancer decreased,apoptosis in HP( ) cases was more prominent than that in HP(-) cases.After eradication of HP,apoptosis was significantly decreased.This indicated that HP might induce apoptosis of gastric epithelial cells,and inhibition in apoptosis might be one of the mechanisms of carcinogenesis.It is suggested that eradication of HP to reduce apoptosis may help prevent pathological changes of gastric mucosa. |
| |
| Keywords: | helicobacter pylori apoptosis precancerous conditions stomach neoplasm/etiology |
| 本文献已被 维普 等数据库收录！ |
|
