Health-related quality of life and psychological correlates in patients listed for liver transplantation |
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Authors: | Jolie J Gutteling Robert A de Man Jan J V Busschbach Anne-Sophie E Darlington |
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Institution: | (1) Department of Gastroenterology and Hepatology, Erasmus MC, ’s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands;(2) Department of Medical Psychology and Psychotherapy, Erasmus MC, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands |
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Abstract: | Purpose Given the increasing waiting time for liver transplantation, and the amount of possible stressors associated with it, assessment
of psychological well-being and health-related quality of life (HRQoL) in these patients is warranted in order to optimize
pretransplant care.
Patients and methods Patients with chronic liver disease (n = 32) awaiting transplantation completed a series of questionnaires measuring HRQoL, depression, anxiety, coping, and self-efficacy.
Comparisons were made with other patients with liver disease with and without cirrhosis, and a healthy norm population. Relationships
among these psychological variables were explored and subgroup analyses were performed to assess possible differences in coping
strategies.
Results Compared to other patients with liver disease without cirrhosis, liver transplant candidates had statistically significantly
lower HRQoL scores on the subscales of physical functioning (P < 0.001) and general health (P < 0.001). Their HRQoL did not differ from patients with liver disease with cirrhosis. Overall, patients awaiting liver transplantation
had significantly reduced HRQoL (P < 0.001) and increased depression scores (P < 0.001) compared to healthy controls. Levels of depression, anxiety, self-efficacy, and coping did not differ between liver
transplant candidates and other patients with liver disease. Depression correlated significantly with HRQoL. Patients without
depression made significantly more use of active coping strategies than patients with elevated depression levels.
Conclusions Patients awaiting liver transplantation are not experiencing worse physical and psychological HRQoL than other liver patients
with cirrhosis of the liver. Therefore, there is currently no indication to increase the level of psychosocial care for liver
transplant candidates. |
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Keywords: | Liver Transplantation Quality of life HRQoL |
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