格列美脲联合地特胰岛素与格列美脲联合二甲双胍治疗2型糖尿病的比较

目的探讨格列美脲联合地特胰岛素治疗2型糖尿病的疗效。方法选择2型糖尿病60例,随机分为两组。治疗组(n=30)为格列美脲早餐前口服+地特胰岛素睡前皮下注射;对照组(n=30)为格列美脲早餐前口服+二甲双胍晚餐后口服。根据血糖监测调整药物剂量,12周后观察两组糖化血红蛋白、空腹血糖、餐后2h血糖、低血糖发生率、BMI、胃肠道反应。结果格列美脲联合地特胰岛素治疗2型糖尿病,不仅能使血糖达标,而且不增加体重,无胃肠道不良反应,发生低血糖风险小,患者依从性好,是治疗2型糖尿病的一种较理想选择。结论格列美脲联合地特胰岛素与格列美脲联合二甲双胍治疗2型糖尿病均可有效降低血糖,两组HbA1c、FBG、2hPBG差异无统计学意义,P>0.05。

Comparison of Glimepiride/Insulin Detemir and Glimepiride Tablets/Metformin combination treatment of type 2 diabetes

Objective To examine the effect of Glimepiride/Insulin Detemir combination treatment of type 2 diabetes.Methods Selected 60 cases of type 2 diabetes,were randomly divided into two groups.Treatment group,Glimepiride/Insulin Detemir combination therapy(n=30);control group,Glimepiride/Metformin combination therapy(n=30).The treatment group Glimepiride oral before breakfast and insulin detemir before bedtime subcutaneous injection,the control group Glimepiride oral before breakfast and after dinner,Metformin oral,adjust the dose according to blood glucose monitoring.After 12 weeks,two groups of glycated hemoglobin,fasting glucose,2-hour postprandial.blood glucose,incidence of low blood sugar,BMI,and gastrointestinal reactions.Results Glimepiride/Insulin Detemir combination treatment of type 2 diabetes,not only make the blood glucose control,and do not gain weight,there is nogastrointestinal side effects and little risk of hypoglycemia,patients with good compliance,is an ideal choice for the treatment of type 2 diabetes.Conclusion Two groups of treatment for type 2 diabetes all can effectively reduce blood sugar,of which HbA1c,FBG and 2h PBG was not statistically significant,P>0.05.