尿微量蛋白在高胆红素血症新生儿中测定的意义

目的 探讨尿微量蛋白在高胆红素血症新生儿中测定的意义.方法 本研究共纳入新生儿74例,分为高胆红素血症组和正常对照组,抽取患儿静脉血测定胆红素和血清尿素氮、肌酐水平；同时收集尿液行尿常规检查,并以放射免疫法检测尿中4种微量蛋白(ALB,TRF,α1-MG,β 2-MG)含量.结果 高胆红素组和对照组患儿肾功能及尿常规检测均正常,但高胆红素血症患儿尿中ALB,TRF,α1-MG,β2-MG水平随着血清总胆红素水平增高而增高；在血清总胆红素水平≤256.5 μnol/L时,仅a1-MG、β2-MG与对照组比较差异有统计学意义.当血清中总胆红素水平＞256.5μmol/L时,尿中ALB,TRF,α1-MG,β2-MG均升高明显,与对照组比较差异有统计学意义(P＜0.01).结论 新生儿高胆红素血症能导致不同程度的肾功能损害,尿微量蛋白测定可作为其早期检测指标之一.

The function of urinary microdose protein in neonates with hyperbilirubinemia

Objective To investigate the function of urinary microdose protein in neonates with hyperbilirubinemia.Methods The contents of ALB,TRF,α1-MG,β2-MG in urine were detected in 39 neonates with hyperbilirubinemia,the blood bilirubin and creatine were also tested;35 healthy subjects served as control group.Results The level of urinary microdose protein is increasing with bilirubin,α1-MG and β2-MG are higher than normal when bilirubin>220μmol/L;moreover,when bilirubin>256μmol/L,contents of ALB,TRF,α1-MG,β2-MG increased significantly.Conclusion Hyperbilirubinemia can damage the renal function of neonates,urinary microdose protein is a useful biomarker for early diagnosis.