急性重症颅脑损伤患者应用亚低温治疗的临床分析

目的分析研究亚低温治疗急性重症颅脑损伤的疗效及影响因素。方法前瞻性分析1996年1月～2011年6月期间我院急性重症颅脑损伤患者178例,在SPSS 17.0统计软件包中行检验比较两组疗效差异,并将年龄、就诊时间、亚低温治疗、初诊GCS评分(Glasgow coma scale,GCS)纳入logistic回归模型进行非条件多因素分析影响亚低温疗效的因素。结果检验比较亚低温组和常规治疗对照组的预后结果显示差异有统计学意义,P<0.05。logistic回归分析显示患者年龄增大、就诊时间长、初诊GCS评分低为影响急性重症颅脑损伤预后的危险因素,P<0.05,而亚低温治疗[β=-0.753,P=0.012,OR值=0.523,95%CI=(0.356,0.866)]则为保护性因素,P<0.05。结论亚低温治疗能够改善急性重症颅脑损伤患者预后,值得进一步推广应用。

A clinical analyses of mild hypothermia on acute traumatic brain injury

Objective To study the efficacy of mild hypothermia on traumatic brain injury.Methods 178 cases of acute traumatic brain injury were randomly divided into hypothermia and control groups.All patients were treated with routine methods.The patients in the hypothermia group received mild hypothermia treatment,and the controls didn’t.The clinical data was collected and analyzed by chis-square test or unconditioned logistic regression in SPSS 17.0 software(P=0.05).Results The prognosis of hypothermia group was significantly better than that of the control group(P<0.05),and logistic regression stated mild hypothermia might be a protecting factor(P<0.05) in the therapy of traumatic brain injury.Conclusion The mild hypothermia could better the prognosis of patients with traumatic brain injury,and should be widely taken advantaged.