| cathepsin B和cystatin C在人脑胶质瘤中的表达及意义 |
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| 引用本文： | 方凤奇,马坚妹,张洁,于佩瑶. cathepsin B和cystatin C在人脑胶质瘤中的表达及意义[J]. 四川医学, 2012, 33(5): 737-739 |
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| 作者姓名： | 方凤奇 马坚妹 张洁 于佩瑶 |
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| 作者单位： | 1. 大连医科大学附属第一医院肿瘤科,辽宁大连,116011
2. 大连医科大学解剖教研室,辽宁大连,116044 |
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| 基金项目： | 辽宁省自然科学基金资助项目 |
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| 摘 要： | 目的探讨半胱蛋白酶抑制剂C(cystatin C)和组织蛋白酶B(cathepsin B)在人脑胶质瘤组织中的表达及意义。方法通过免疫组织化学法检测cystatin C及cathepsin B在57例不同分化程度的脑胶质瘤组织中的表达。结果cystatin C在低分化胶质瘤(III-IV级)中的表达低于高分化者(I～II级),而cathepsin B在低分化胶质瘤中的表达高于高分化者(P<0.05)。cystatin C和cathepsin B在脑胶质瘤中的表达呈负相关(P=0.01)。结论 cystatin C和cathepsin B的表达与人脑胶质瘤病理分级及侵袭性相关。联合检测cystatin C和cathepsin B的表达,可为脑胶质瘤的侵袭性及临床恶性程度评估提供重要信息。
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| 关 键 词： | 脑胶质瘤 cathepsin B cystatin C |
Expression and significance of Cathepsin B and Cystatin C in human gliomas |
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| Affiliation: | FANG Feng-qi1,MA Jian-mei2,ZHANG Jie1,et al. 1.The 1st Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011;2.Dalian Medical University,Dalian,Liaoning 116044,China |
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| Abstract: | Objective To explore the expression and significance of cystatin C and cathepsin B in human gliomas.Methods A immunohistochemical method was used to detect the expression of cystatin C and cathepsin B in 57 glioma samples.Results The expression of cystatin C in high-grade(Grade III-IV)gliomas was significantly weaker than that in low-grade(Grade I-II).On the other hand,the expression of cathepsin B in high-grade gliomas was significantly stronger than that in low-grade(P<0.05).Cystatin C expression correlated inversely with cathepsin B expression in gliomas(P=0.01).Conclusion Cystatin C and cathepsin B expression is related to the pathological grade and invasion of gliomas.Combining detection of cystatin C and cathepsin B expressions might provide significant information for clinical assessment of maglignant phenotypes and invasion of gliomas. |
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| Keywords: | gliomas cathepsin B cystatin C |
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