含铋剂四联疗法根除幽门螺杆菌疗效观察

目的 探讨合铋剂四联疗法治疗消化性溃疡Hp感染初治者的疗效.方法 将138例消化性溃疡Hp感染初治者随机分成治疗组和对照组.治疗组70例患者给予胶体果胶铋+泮托拉唑+克拉霉素+阿莫西林；对照组68例患者给予泮托拉唑+克拉霉素+阿莫西林.两组患者均完成1周治疗,治疗结束后4周对根除Hp的疗效进行观察.结果 治疗组和对照组Hp根除率分别为87.14％(61/70)和73.53％(50/68),差异有统计学意义(ｘ2=4.06,P＜0.05).结论 含铋剂四联疗法用于消化性溃疡Hp感染初治者的疗效好于标准三联疗法.

Clinical study of eradication of helicobacter pylori with bismuth-based quadruple therapy

Objective To observe the effect of eradicating helicobacter pylori(Hp) with bismuth-based quadruple therapy on treating peptic ulcer.Methods A total of 138 patients with peptic ulcer and Hp infection were allocated to two groups.The treatment group(n=70) received colloidal bismuth pectin 200mg bid,pantoprazole 40mg bid,amoxicillin 1.0g bid and clarithromycin 500mg bid for 7 days;the control group received pantoprazole 40mg bid,amoxicillin 1.0 g bid and clarithromycin 500mg bid for 7 days.Following the treatment,14C urea breath test was performed to observe the Hp eradication rate.Results The eradication rate of bismuth-based quadruple therapy was 87.14%,and that of control group was 73.53%.The difference between two groups was significant(P<0.05).Conclusion Compared to the standard triple therapy regimen,the bismuth-containing quadruple therapy regimen has higher eradication rate.