肺炎支原体感染患儿血清白介素-5 和尿白三烯E4的水平变化及临床意义

目的:观察肺炎支原体感染患儿血清白介素-5(IL-5)和尿白三烯E4(LTE4)的水平变化,探讨IL-5和半胱氨酰白三烯(cysLTs)在肺炎支原体感染发病机制中的作用。方法:住院确诊为MP感染的患儿为MP感染组(29例),同期在门诊作正常健康体检的儿童为正常对照组(30例)。用双抗体夹心ELISA法检测两组儿童血清IL-5和尿LTE4的浓度。结果:MP感染组尿LTE4的水平显著高于正常对照组(P<0.01);MP感染组血清IL-5的水平与正常对照组无显著性差异(P>0.05)。MP感染患儿血清IL-5的水平和尿LTE4的水平无相关性(P>0.05)。结论:cysLTs在MP感染的发病机制中起一定作用,IL-5可能不是MP感染的发病机制的重要因素。

The Change and Clinical Significance of Serum IL-5 and Urine LT E4 in Children with MP Infection

Objective: To observe the change of serum IL-5 and urine LTE4 in patients with MP infection, and explore the value of IL-5 and cysLTs on the MP infection Methods: The MP infection group (29) was children diagnosed with MP infection in clinical, and the normal control group (30) was healthy children with routing physical examinations in outpatient department All were tested the serum concentration of IL-5 and the urine concentration of LTE4 by ELISA Results: The urine concentration of LTE4 in the MP infection group was significantly higher than that in the normal control group (t=5718, P < 001), but there was no significant difference for the serum concentration of IL-5 in the MP infection group and the normal control group (t=1604, P > 005) There was no correlation between the serum IL-5 and the urinary LTE4 (r=-0086, P > 005) Conclusion: cysLTs plays some roles in the pathogenesis mechanisms of MP infection while IL-5 might be not an important factor