| 胃泌素及其受体拮抗剂对BGC－823细胞系生长的调节 |
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| 引用本文： | 王俊平,黄乃霞,黄象谦,吴琳.胃泌素及其受体拮抗剂对BGC－823细胞系生长的调节[J].胃肠病学和肝病学杂志,1996(4). |
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| 作者姓名： | 王俊平 黄乃霞 黄象谦 吴琳 |
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| 作者单位： | 天津医科大学消化科 |
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| 摘 要： | 本文用液闪测定和细胞计数观察了胃泌素及其受体拮抗剂丙谷胺和Ｌ－３６５２６０对体外培养的人胃腺癌ＢＧＣ－８２３细胞系的生长调节作用。结果表明不同浓度胃泌素对ＢＧＣ－８２３细胞系的生长均有显著促进作用，而这种作用可被其受体拮抗剂丙谷胺和Ｌ－３６５２６０所抑制，且发现在胃泌素浓度衡定时，Ｌ－３６５２６０对ＢＧＧ－８２３细胞系的生长抑制作用明显强于丙谷胺。这一结果也提示，Ｌ－３６５２６０对胃泌素受体的亲合力可能明显高于丙谷胺。
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| 关 键 词： | 胃泌素，丙谷按，L－365260，人胃癌BGC－823细胞系，生长调节 |
Growth regulating action of gastrin and gastrin receptor antagonist on human gastric tumor cell line cultured in vitro |
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| Wang Jun-ping,Huang Nai-xia,Huang Xiang-qian.Growth regulating action of gastrin and gastrin receptor antagonist on human gastric tumor cell line cultured in vitro[J].Chinese Journal of Gastroenterology and Hepatology,1996(4). |
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| Authors: | Wang Jun-ping Huang Nai-xia Huang Xiang-qian |
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| Abstract: | In this study,the effect of gastrin and gastrin receptor antagonist L-365260,proglumide on the growthe of human gastric cancer cell line BGC-823 was investigated using3H-TdR incorportion and direct cell countsat a parameter for cell growth. The results indicalted that gastrinsignificantly promoted growth of human gastric cancer cell line GBC-823 ,this effect could be inhibited by gastrin receptor antagonist L-365260 ,proglumide.But we finded that L-365260 has greater inhibition than proglumide . |
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| Keywords: | gastrin Human gastric cancer cell line BGC-823 L-365260 Proglumide Growth-regulating action |
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