| 伴三系病态造血初发性急性髓细胞白血病实验和临床分析 |
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| 引用本文： | 龚五星,陈晖. 伴三系病态造血初发性急性髓细胞白血病实验和临床分析[J]. 白血病．淋巴瘤, 2000, 0(2) |
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| 作者姓名： | 龚五星 陈晖 |
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| 作者单位： | 暨南大学医学院附三院珠海市人民医院!广东珠海519000 |
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| 摘 要： | 目的 :观察 AML - TMDS在 FAB各亚型的分布、血液学特征和临床化疗效果。方法 :对 AML -TMDS和无 TMDS的 AML 两组 ,进行血象、骨髓细胞形态、骨髓原始细胞计数以及化疗首次完全缓解率的比较。结果 :96例初发 AML 中 ,有 11例为 AML- TMDS(占 11.5 % ) ,见于 M2 、M5 、M6 ,在 M1 、M3中未见到 ;Hb、WBC、BPT无显著性差异 (P>0 .0 5 ) ,骨髓原始细胞计数 AML- TMDS较低 ,两组比较有显著性差异 (P<0 .0 5 ) ,化疗首次完全缓解率无 TMDS的 AML组 (6 2 .7% )较 AML - TMDS组 (46 .5 % )明显降低 (P<0 .0 5 )。结论 :AML - TMDS对化疗不敏感 ,首次完全缓解率低 ,预后不良。
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| 关 键 词： | 急性白血病 病态造血 化学治疗 |
THE STUDY AND CLINIC ANALYSIS OF ACUTE MYELOID LEUKAEMIA WITH TRILINEAGE MYELODYSPLASIA |
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| Abstract: | Objective:To observe the distribution of AML TMDS on subvarieties of FAB,hemopathologic character and clinical chemotherapic effect.Methods:Dividing the patients into two groups:AML TMDS and AML without TMDS and comparing the blood,cellular morphosis of bone marrow,immature cell counts of bone marrow and CR 1.Results:Among 96 AML patients,there are 11 AML TMDS (11.5%),which are M 2,M 5,M 6 separately but without M 1,M 3.There is no significant difference in Hb,WBC,BPT ( P >0.05).AML TMDS have lower immature cell counts of bone marrow (P <0.05),CR 1 is 62.7% in AML without TMDS and 46.5% in AML TMDS( P< 0.05).Conclusions:In AML TMDS,there is obviously pathological hemogenesis in the three series of hemogenic cells,with low sensitivity to chemotherapy and low CR 1. |
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| Keywords: | Acute leukaemia Pathological hemogenesis Chemotherapy |
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