帕罗西汀治疗腹泻型肠易激综合征临床疗效观察

目的：观察帕罗西汀治疗腹泻型肠易激综合征（D—IBS）的疗效，并探讨抗抑郁药在治疗D-IBS中的作用和地位。方法：在常规疗法基础上，联用帕罗西汀治疗66例顽固性腹泻型肠易激综合征（D-IBS）8周，并与单用常规疗法58例对照，评测其治疗前后消化道症状和焦虑、抑郁自评量表积分变化。结果：帕罗西汀组的消化道症状有效率分别为57．6％，显著高于常规疗法的24．1％（P〈0．01）；帕罗西汀组原有情绪障碍患者和无情绪障碍患者的消化道症状有效率分别为67．4％和29．4％，有显著差异（P〈0．05）；帕罗西汀组治疗前后焦虑自评量表（SAS）总分差值、抑郁自评量表（SDS）总分差值比较则显著改善（P〈0．01）。结论：帕罗西汀能改善D-IBS的消化道症状，并与目前是否存在情绪障碍相关。

A clinical trial of paroxetine for the treatment of diarrhea type irritable bowel syndrome

Objective：To evaluate the efficacy of paroxetine in the treatment of diarrhea type irritable bowel syndrome （D-IBS）as compared with the routine treatment ,and to study the functions and positions of anti-depressive drugs in the treatment of IBS. Methods： A total of 124 patients with D-IBS were randomly selected to receive paroxetine（66 cases ） and the routine treatment（58 cases） for 8 weeks. Results：The efficacy of paroxetine（57.6% ）was significantly better than that of routine treatment （24.1% ） （P 〈 0. 01 ）. The efficacy was dependent on the psychological states of the patients. The self-rating anxiety scale scores and self - rating depression scale scores of the patients who received paroxetine treatment were decreased significantly after treatment （P 〈 0.01 ）. Conclusion： Paroxetine can improve the patients with D-IBS significantly both in the spiritual and somatic symptoms.