Ganglioside antibodies: a lack of diagnostic specificity and clinical utility? |
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Authors: | Weller Michael Stevens Andreas Sommer Norbert Dichgans Johannes Kappler Bettina Wiethölter Horst |
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Institution: | (1) Neurologische Universitätsklinik, Hoppe-Seyler-Strasse 3, W-7400 Tübingen, Germany;(2) Clinical Neuroscience Branch, Building 10, Room 3N256, National Institute of Health, 20892 Bethesda, MD, USA;(3) Psychiatrische Universitätsklinik, Osianderstrasse 22, W-7400 Tübingen, Germany |
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Abstract: | Summary Serum IgG and IgM antibodies to gangliosides GM1, GM2, GM3, AGM1, GD1a, GD1b and GT1b were determined in 210 patients with different degenerative and inflammatory disorders including motor neuron diseases, peripheral radiculopathies and neuropathies, multiple sclerosis and neuroborreliosis. No single disorder was associated specifically with ganglioside antibodies. No characteristic patterns of ganglioside antibodies were observed in any disease category. However, 32% of all patients had pathological antibody titres to at least one ganglioside. Four patients had pathological IgG and IgM titres for all gangliosides evaluated. They suffered from systemic lupus erythematosus 2], neuroborreliosis and schizophrenia, respectively. The results of this study indicate that the introduction of ganglioside antibody determination as a differential diagnostic test in clinical neurology is only helpful in a few patients with typical lower motor neuron syndromes. |
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Keywords: | Ganglioside antibodies Neurological disorders Enzyme-linked immunosorbent assay |
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