LT受体拮抗剂对大鼠肺纤维化LTB4及血Fn的影响

45只大鼠随机分为3组，对照组、模型组、治疗组各15只。治疗组气定内单次灌注博莱霉素（5mg)后每日以安可来（ACL，10mg/kg)灌胃；模型组气管内灌注同治疗组，灌胃以生理盐水代替。3组动物在气管内灌注后分别于第7、14、28d随机处死5只，取左肺下叶1g匀浆测LTB4，心腔血测纤维联结蛋白（Fn)。模型组和治疗组在气管内灌注后白三烯B4（LTB4）迅速上升，第7d达高峰，第28d模型组LTB4仍较高，治疗组LTB4明显下降；Fn浓度模型组在第7d明显升高，治疗组及对照组较低。结论：在鼠实验性肺间质化过程中LTB4明显增高，白三烯对肺间质纤维化的发生发展起一定作用。

The Effect of LT-receptor Antagonist to LTB4 and Fn in Pulmonary Fibrosis

Forty-five rats were divided into three groups in random controlgroup, untreated model group, ACL-treated group. On experimental Day(Day O),the rats were intratracheally instilled Bleomycin (5 mg/kg)or sterile saline, and then treated with ACL(10mg/kg)or saline until they were killed. At the date of 7th,14th,28th after instillation,fifteen rats of each group were sacrificed, the 1.0 gram lower lobe of left lungs were harvested and jellied for determination of LTB4，the blood was collected for determination of Fn. After BLM instillation,LTB4 of treated group and model group was elevated quickly and peaked at 7th day, then treated group declined notably but model group slowly. Fn of model group was much more elevated than that of other group's, Conclusions: LTB4 acts on an important role in the development of pulmonary fibrosis