血吸虫病与原发性肝癌关系的队列研究

为探讨日本血吸虫病与原发性肝癌的关系, 对大丰市455 人进行了12年的前瞻性观察。血吸虫病组表抗携带率为14.21% , 比非血吸虫病组的9.56% 高; 肝癌20岁以上截缩标化人年死亡率, 血吸虫病组为283.82/10 万, 非血吸虫病组为38.66/10万, RRM H为5.72,SMR分别为3.76 和0.65,P< 0.01;前者组内男女肝癌死亡率比RRM H 为1.51, P> 0.05,后者组内RRM H 为3.98,P< 0.01。用叉生法分析血吸虫病和表抗携带两因素的作用,则肝癌20岁以上截缩标化人年死亡率,血吸虫病和表抗携带双阴者为21.16/10万, 血吸虫病单阳者为118.47/10 万,表抗携带单阳者为232.33/10 万,血吸虫病和表抗携带双阳者为1228.75/10 万; 后三者与前者相比, RRM H 分别为3.99, 8.47, 34.57, P均< 0.01; 血吸虫病和表抗携带对肝癌联合作用指数S为3.2,Poisson 回归乘法模型拟合良好。结果提示两者与肝癌分别有密切联系,且有明显的相乘作用

A COHORT STUDY ON LIVER CANCER AND SCHISTOSOMIASIS JAPONICA.

In all 4551 persons were followed up for 12 years for a prospective study in Dafeng.HBsAg carrying rate was 14 2% in schistosomiasis group,and was 9 58% in nonschistosomiasis group,which was significantly defferrent between the two groups.Truncated standardized death rate of the age group over 20 was 283 82/10 5 in schistosomiasis group,and was 38 66/10 5 in nonschistosomiasis group.Both was compared:RR MH was 5 72,SMR was 3 76 in the former,SMR was 0 65 in the latter ,P <0 01.In male and female,RR MH was 1 51, P> 0 05 in the former,and was 3 98, P <0 01 in the latter.In the case of liver cancer,we studied interaction on schistosomiasis and HBsAg carrying state.Truncated standardied death rate of the age group over 20 was 21 16/10 5 in negative both,and was 118 47/10 5 in simple schistosomiasis,and was 232 33/10 5 simple HBsAg carrier,and was 1228 75/10 5 in positive both.In the three latter compare with in the former.RR MH was each 3 99,8 47,34 75,all P <0 01.Synergy index was 3 2.Poisson regression model was ritted better.The results show they all had closly relations with the liver cancer and significant multiplication effect no interaction.