孕产妇HBV感染相关因素的病例对照研究

收集１９９７年２月至１１月间ＨＢｓＡｇ阳性孕产妇１００例，同期收集健康孕产妇１０９例进行孕产妇ＨＢＶ感染影响因素的病例对照研究。多因素分析表明ＨＢＶ感染者接触史、频繁在外用餐、街头摊点用餐及出生于南方为孕产妇ＨＢＶ感染的危险因素，乙肝疫苗接种为保护因素。分级分析表明暴露于父母ＨＢＶ感染家庭的孕产妇ＨＢＶ感染的估计相对危险性（１６．０９）分别大于暴露于同胞（６．１３）、丈夫（５．１１）及其他（１．８４）ＨＢＶ感染者。结果提示：父母ＨＢＶ感染史、ＨＢＶ感染家族史、频繁在外用餐、街摊用餐及出生地对孕产妇ＨＢＶ感染影响较大，而经血传播并非孕产妇ＨＢＶ感染的主要途径。

A CASE CONTROL STUDY ON RELATIVE FACTORS OF HBV INFECTION IN PREGNANT WOMEN.

One hundred HBsAg positive pregnant women and one hundred and nine healthy pregnant women were collected from February to November,1997 and a case control study on determinants of HBV infection in pregnant women was conducted.The multiple logistic regression analysis showed that the history of contaction with hepatitis B patients or carrier,the family history of HBV infection,the history of parents HBV infection,eating meals outside,eating meals on stall and born in the southern part of the country were risk factors and vaccinated with HB vaccine was protective factor of HBV infection in pregnant women.The grade analysis of risk factors indicated that the odds ratio of HBV infection in pregnant women exposing to HBV infected parents(16 09) was high than that in those exposed to infected full sisters and brothers(6 13),Husbands(5 11) and other persons(1 84),respectively.The result suggests that above mentioned risk factors might play important roles in HBV infection in pregnant women,but blood born transmission of HBV infection might not be major route.