输血后肝炎流行现状及预防措施评价

采用队列研究方法，对202例受血者和65例手术未受血者PTH流行现状及献血员HBsAg和抗-HCV筛检的效果进行了研究。结果表明，71例输入未经抗-HCV筛检血液者丙肝罹患率为16．9％，131例输入经筛检血液者为1．5％，前者抗-HCV阳转率为33．8％，后者为9．1％，65例未受血手术者抗一HCV阳转率为1．5％，未发现显性感染者。202例输入经HBsAg筛检血液者HBV感染标志阳转率为25．2％，65例未经受血手术者为4．6％。结果提示，献血员HBsAg和抗-HCV筛检能有效降低输血后乙、丙型肝炎罹患率和病毒感染率。但对病毒含量低的供血者仍不能检出。

THE CURRENT RISK OF POST-TRANSFUSION HEPATITIS AND SIGNIFICANCE OF SCREENING FOR ANTI-HCV AND HBsAg IN BLOoD DONORS.

A survey in 202 patients who received blood transfusion and 65 patients who not transfused at least 6 months after surgery was conducted. The serum samples were tested for anti-HCV and HBsAg, anti-HBc, anti-HBs by enzyme immunoassay. The results showed that of the 71 patients who received blood transfusion before donors were screened fol anti-HCV, 12 occurred hepatitis C, the attack rate was 16. 9%, and 24 sero-converted to HCV, the sero-converted rate was 33. 8 %. Of 131 patients who received blood transfusion after donors were screened for anti-HCV, only 2 occurred hepatitis C, the attack rate was1. 5%, the sero-converted rate to HCV was 9. 1 %. Of 65 patients who did not receive transfusions but underwent surgery, seroconverted rate to HCV was 1. 5%. The risk of sero-conversion to HCV was strongly associated (P<0. 001 ) with volume of bloodtransfused. Of 202 patients who received transfusions after screened for HBsAg, 51 sero-converted; HBV markers. the underwent rate was 25. 2%. The sero-converted rate in patients who were not transfused but underwent surgery was 4. 6 %. noclinical potient of hepatitis B was found.