| 核苷类抗HIV药物的研究与开发 |
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| 引用本文： | 詹天荣,娄红祥. 核苷类抗HIV药物的研究与开发[J]. 药学进展, 2005, 29(7): 289-295 |
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| 作者姓名： | 詹天荣 娄红祥 |
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| 作者单位： | 山东大学药学院,山东,济南,250012 |
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| 基金项目： | 国家自然科学基金资助项目(30271537) |
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| 摘 要： | 综述近年来核苷类抗HIV药物的研究与开发,着重介绍若干嘧啶核苷类和嘌呤核苷类抗HIV化合物,并探讨其作用机制和该类药物的研发策略。
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| 关 键 词： | 核苷类似物 抗HIV活性 作用机制 结构修饰 |
| 文章编号： | 1001-5094(2005)07-0289-07 |
| 修稿时间： | 2005-01-23 |
Research and Development of Nucleoside Anti-HIV Drugs |
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| ZHAN Tian-rong,LOU Hong-xiang. Research and Development of Nucleoside Anti-HIV Drugs[J]. Progress in Pharmaceutical Sciences, 2005, 29(7): 289-295 |
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| Authors: | ZHAN Tian-rong LOU Hong-xiang |
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| Affiliation: | ZHAN Tian-rong,LOU Hong-xiang * |
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| Abstract: | The research and development of nucleoside anti-HIV drugs in recent years were reviewed. A number of pyrimidine nucleoside and purine nucleoside anti-HIV compounds were mainly introduced. Their mechanism of action and the strategy on research and development of them were also discussed. |
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| Keywords: | Nucleoside analogue Anti-HIV activity Mechanism of action Structural modification |
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