Study on immunofunction and immunoregulation post newcastle disease vaccination of chickens infected with chicken anemia virus |
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Authors: | LIU Zhong-gui ZHENG Shi-min XU Yan-bo ZHOU Zhi-yong YANG Li-ping LI Guang-xing AhmatMamat |
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Institution: | LIU Zhong-gui,ZHENG Shi-min,XU Yan-bo,ZHOU Zhi-yong,YANG Li-ping,LI Guang-xing,Ahmat*Mamat |
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Abstract: | Chickens were infected with chicken anemia virus (CAV) at one-day-old and vaccinated with La Sota vaccine 8 days later. Meanwhile, uninfected chickens were vaccinated as controls. At 7, 14 and 28 days post vaccination, the content of IgG,IgM,IgA and HI titer in serum, the number of T cells, IgG, IgM and IgA antibody producing cells in thymus, bursa and spleen, the proliferative response of T、B cells, the inductive activity of interleukin 2 (IL-2) and interferon (IFN) in thymus and spleen were tested. The results showed that the content of IgG, IgM, IgA and hemoagglutination inhibition (HI) titer in serum, the number of T cells, IgG, IgM and IgA antibody producing cells in thymus, bursa and spleen, the proliferative response of T cells and B cells as well as the inductive activity of IL-2 and IFN in thymus and spleen of infected-vaccinated chickens significantly decreased compared with the control. These results indicated that the immunofunction and immunoregulation were dropped post ND vaccination of CAV-infected chickens. |
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