| [~(125)I]-(A14)单碘胰岛素在荷人肝癌裸鼠体内的趋瘤特性研究 |
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| 引用本文： | 丁勇,吴秋莲,徐浩,吴春云. [~(125)I]-(A14)单碘胰岛素在荷人肝癌裸鼠体内的趋瘤特性研究[J]. 中国病理生理杂志, 2001, 0(7) |
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| 作者姓名： | 丁勇 吴秋莲 徐浩 吴春云 |
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| 作者单位： | 暨南大学医学院第一附属医院科研科!广东广州510632(丁勇)，暨南大学医学院附属护校!广东广州510632(吴秋莲)，暨南大学医学院第一附属医院核医学科!广东广州510632(徐浩)，暨南大学医学院寄生虫学教研室!广东广州510632(吴春云) |
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| 基金项目： | 广东省自然科学基金资助项目 (No .970 6 2 5 ) |
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| 摘 要： | 目的 :观察放射性碘标记胰岛素在荷人肝癌裸鼠体内的趋瘤或亲肿瘤 (tumor-seeking)特性。方法 :采用荷人肝癌裸鼠模型。用 [12 5I]- (A14)单碘胰岛素进行荷人肝癌裸鼠体内分布实验和抑制实验。结果 :体内分布实验显示肝癌组织摄取 [12 5I]- (A14)单碘胰岛素明显高于本底组织 (肌肉 ) ,肿瘤与血和肿瘤与肌肉的放射性比值随时间延长而增高。体内抑制实验发现肿瘤组织于 30min的抑制率为 35 .0 %。结论 :[12 5I]- (A14)单碘胰岛素在荷人肝癌裸鼠体内 ,通过受体介导作用 ,能被肝细胞癌组织特异性摄取。
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| 关 键 词： | 胰岛素 放射性同位素 碘 肝细胞瘤 小鼠 裸 |
The tumor-seeking specificity of [~(125)I]-(A14)-insulin in human hepatoma bearing nude mice |
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| DING Yong ,WU Qiu lian ,XU Hao ,WU Chun yun. The tumor-seeking specificity of [~(125)I]-(A14)-insulin in human hepatoma bearing nude mice[J]. Chinese Journal of Pathophysiology, 2001, 0(7) |
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| Authors: | DING Yong WU Qiu lian XU Hao WU Chun yun |
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| Affiliation: | DING Yong 1,WU Qiu lian 2,XU Hao 3,WU Chun yun 4 |
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| Abstract: | AIM: To observe tumor-seeking specificity of [ 125 I]-(A14)-insulin in human hepatoma bearing nude mice METHODS: The in vivo tissue distribution and inhibition studies of [ 125 I]-(A14)-insulin in human hepatoma bearing nude mice were performed RESULTS: In the tissue distribution study, a significant accumulation of [ 125 I]-(A14)-insulin was observed in the tumor site of nude mice The tumor/blood and tumor/muscle radioactive ratio gradually increased with lengthening time following injection of [ 125 I]-(A14)-insulin The inhibition ratio in the tumor tissue of nude mice in the inhibition study was 35 0% CONCLUSION: There is a specific uptake of [ 125 I]-(A14)-insulin through receptor-mediated process in the hepatoma tissue of nude mice [ |
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| Keywords: | Insulin Radioisotopes Iodine Hepatoma Mice nude |
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