| 鼻咽癌中环氧化酶-2和潜伏膜蛋白-1的表达和相互关系的初步研究 |
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| 引用本文： | 白薇琦,汤建国. 鼻咽癌中环氧化酶-2和潜伏膜蛋白-1的表达和相互关系的初步研究[J]. 临床耳鼻咽喉头颈外科杂志, 2009, 23(3): 105-108 |
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| 作者姓名： | 白薇琦 汤建国 |
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| 作者单位： | 1. 宁波市第二医院耳鼻咽喉科,浙江宁波,315010
2. 浙江大学医学院附属邵逸夫医院耳鼻咽喉-头颈外科 |
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| 摘 要： | 目的：探讨鼻咽癌组织中的环氧化酶2（COX-2）、潜伏膜蛋白-1（LMP1）的表达情况，同时分析了两者之间的关系。方法：53例鼻咽癌活检标本，8例鼻咽部慢性炎症常规石蜡切片标本作为对照组，用SP免疫组织化学法检测COX-2、LMP1的表达，采用sPsS12．0统计软件对实验数据进行统计。结果：在鼻咽癌组织中，COX-2阳性表达率为71．70％（38／5a）；LMPI阳性表达率为66．04％（35／53）。COX2、LMP1的表达在颈部淋巴结转移组中均明显高于无颈部淋巴结转移组（P％O．05），但在年龄、性别、病理类型、临床分期的分组中均差异无统计学意义（均P〉0．05）。在鼻咽癌组织中，LMP1和COX-2的表达存在正相关（7—0．797，P〈0．01）。结论：COX-2、LMP1在鼻咽癌组织中均有表达。COX2、LMP1在鼻咽癌中的表达和鼻咽癌颈淋巴结转移存在显著相关性，但和年龄、性别、病理类型、临床分期无相关性。COX-2和LMP1在鼻咽癌组织中的表达呈正相关。LMP1可能通过多途径上调COX-2的表达，从而促进鼻咽癌颈部淋巴结转移。
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| 关 键 词： | 鼻咽肿瘤 环氧化酶-2 EB病毒 潜伏膜蛋白1 |
The expression and relationship of cyclooxygenase-2 and latent membrane protein-1 in nasopharyngeal carcinoma |
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| BAI Weiqi,TANG Jianguo. The expression and relationship of cyclooxygenase-2 and latent membrane protein-1 in nasopharyngeal carcinoma[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2009, 23(3): 105-108 |
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| Authors: | BAI Weiqi TANG Jianguo |
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| Affiliation: | 1Department of Otolaryngology;the Second Hospital of Ningbo City;Ningbo;315010;China;2Department of Otolaryngology-Head and Neck Surgery;the Affiliated Sir Run Run Shaw Hospital of Zhejiang University |
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| Abstract: | Objective:To discuss the expression and correlation of COX2 and LMP1 in NPC.Method:Fifty-three nasopharyngeal biopsy specimens of NPC patients who had been diagnosed definitely with pathology in our department from 2000 to 2005,and 8 nasopharyngeal biopsy specimens of chronic nasopharyngitis patients were collected. The expression of COX2,LMP1 were detected with streptavidin peroxidase immunohistochemistry staining. All the datas were analyzed with SPSS 12.0.Result:The positive expression rate of COX2 was 7... |
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| Keywords: | nasopharyngeal carcinoma cyclooxygenase-2 Epstein-Barr virus latent membrane protein-1 |
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