右美托咪啶用于高血压患者胃肠手术全麻后期的临床观察

目的探讨右美托咪啶用于高血压患者胃肠手术全麻后期的临床效果。方法 36例有高血压病史拟行胃肠手术的患者,随机分为右美托咪啶组(A,n=18)和对照组(B,n=18)。两组常规采用气管内插管静吸全麻,A组于手术结束前40min经静脉微量注射泵泵注0.8μg/kg的右美托咪啶,B组注射等量的0.9%氯化钠注射液。结果右美托咪啶组各时间段的HR和MAP明显低于对照组(P<0.05),心肌缺血发生率和躁动发生率也明显低于对照组(P<0.05)。结论右美托咪啶能有效地减轻苏醒期的血流动力学波动,保护心肌,降低术后躁动发生率。

Clinical observation on the patients with hypertension treated with Dexmedetomidine in the late general anesthesia of gastrointestinal surgery

Objective To investigate the effect of Dexmedetomidine used for the patients with hyper- tension in the late general anesthesia of gastrointestinal surgery. Methods Patients with hypertension scheduled for gastrointestinal surgery, were randomly divided into the Dcxmedetomidine group（A） , the control group （B）, 18 patients in each group. At 40 minutes before the end of operation, injection Dexmedetomidine 0. 8 μg/kg with minipump was adminitered in groud A, but groud B was given the same amount of physiological saline. Results HR and MAP in groud A was significantly lower than the control group B（P 〈 0. 05）. Myocardial damage rate and agitation rate in groud A was significantly lower than group B （ P 〈 0.05 ）. Conclusion Dexmedetomidine can effectively stabilize the hemodynamics status, reduce the myocardial damage rate and the agitation rate.