慢性阻塞性肺疾病合并糖尿病患者肺功能的变化

目的研究慢性阻塞性肺疾病(COPD)患者合并糖尿病时肺功能的变化。方法本研究设单纯COPD组(30例),COPD合并糖尿病组(38例)。将COPD合并糖尿病组患者根据有无微血管病变(眼底和肾脏)及神经系统病变再分为有并发症组(22例)和无并发症组(16例),检测肺活量(VC)、1秒钟用力呼气容积(FEV1)、FEV1/用力肺活量(FVC)、肺一氧化碳弥散(DLCO)及单位肺泡一氧化碳弥散量(DLCO/VA)等肺功能指标,采用SPSS11.5软件进行统计学处理,分别比较单纯COPD组、COPD合并糖尿病有并发症组以及COPD合并糖尿病无并发症组之间各项肺功能指标的差异。结果COPD合并糖尿病有并发症组VC、DLCO及DLCO/VA低于单纯COPD组,差异有统计学意义(P<0.05),COPD合并糖尿病有并发症组DLCO及DLCO/VA低于COPD合并糖尿病无并发症组,3组间FEV1,FEV1/FVC差异无统计学意义。结论COPD合并糖尿病的患者伴有视网膜病变、糖尿病肾病和周围神经病变等微血管病变时,进一步加重了限制性通气障碍。

Analysis of Lung Function in Patients with Chronic Obstrctive Pulmonary Disease Combined with Diabetes Mellitus

Objective Through determination of levels of VC、FEV1、FEV1/FVC、DLCO and DLCO/VA,to investigate the change of lung function in patients with chronic obstructive pulmonary disease(COPD) Combined with diabetes mellitus(DM).Methods Thirty patients with COPD and thirty eight patients with COPD combined with DM were examined and the thirty eight patients with COPD and DM were further divided into 2 groups,22 with DM complication and 16 without. The levels of VC、FEV1、FEV1/FVC、DLCO and DLCO/VA were determined and analysed.Results The levels of VC、DLCO and DLCO/VA were lower in patients with COPD combined with DM with complications than in those with COPD only(P<0.05).The level of DLCO and DLCO/VA were lower in patients with DM complications than in those without(P<0.05).Conclusion In patients with COPD combined with DM,especially with DM complications restrictive ventilatory and diffusion dysfunctions are more aggravated than in those with COPD only.