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| 当归破壁粉粒补血作用及急性毒性实验研究 | |
| 引用本文： | 闵欢,成金乐,陈健文,徐吉银,邓雯,刘培庆,黄芝瑛.当归破壁粉粒补血作用及急性毒性实验研究[J].广东药学院学报,2012,28(1):73-75. |
| 作者姓名： | 闵欢 成金乐 陈健文 徐吉银 邓雯 刘培庆 黄芝瑛 |
| 作者单位： | 1. 中山市中智药业集团有限公司,广东中山528437;广州中医药大学中药资源科学与工程研究中心,广东广州510006 2. 中山市中智药业集团有限公司,广东中山,528437 3. 中山大学药学院,广东广州,510080 |
| 基金项目： | 广东省粤港关键领域重点突破招标项目(20080106-2);广东省科技计划项目(粤科计字[2008]72号);中山市科技强企支撑计划项目(20092A113) |
| 摘 要： | 目的探讨当归破壁粉的补血作用及急性毒性作用。方法建立失血性贫血小鼠模型,以白细胞(WBC)、红细胞(RBC)、血红蛋白(Hb)、血小板(PLT)等血常规指标衡量当归破壁粉粒对贫血的治疗作用,并以当归破壁粉粒及其饮片80 g/kg给小鼠灌胃后7 d,观察其对小鼠的急性毒性。结果当归破壁粉粒能明显改善小鼠贫血指标,且未观察到当归破壁粉粒及其饮片的急性毒性发生。结论当归破壁粉粒具有补血作用且无急性毒性作用。 |
| 关 键 词： | 当归饮片 破壁粉粒 补血作用 急性毒性 |
A study on the effect of the blood enrichment and acute toxicity of cell-wall broken powder of Angelica sinensis |
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| MIN Huan , CHENG Jin-le , CHEN Jian-wen , XU Ji-yin , DENG Wen , LIU Pei-qing , HUANG Zhi-ying.A study on the effect of the blood enrichment and acute toxicity of cell-wall broken powder of Angelica sinensis[J].Academic Journal of Guangdong College of Pharmacy,2012,28(1):73-75. | |
| Authors: | MIN Huan CHENG Jin-le CHEN Jian-wen XU Ji-yin DENG Wen LIU Pei-qing HUANG Zhi-ying |
| Institution: | 1.Zhongzhi Chinese Medicine Industry Group Co.,Ltd.,Zhongshan 528437,China;2.Pharmacy College of Zhongshan University,Guangzhou 510080,China;3.Research Center of Chinese Medicinal Resource Science and Engineering,Guangzhou University of Chinese Medicine,Guangzhou 510006,China) |
| Abstract: | Objective To study the effect of the blood enrichment and acute toxicity of cell-wall broken powder of Angelica sinensis.Methods Establish a hemorrhagic anemia mouse model and measure the effect of the blood enrichment of cell-wall broken powder of Angelica sinensis by WBC,RBC,Hb,PLT and other blood indicators.Then 80 g dried medicinal herbs/kg of cell-wall broken powder and decoction pieces of Angelica sinensis were administrated in mice,and these acute toxic reactions were observed continuously for 7 days.Results Cell-wall broken powder of Angelica sinensis obviously improved blood indicators.No toxic reactions were observed on cell-wall broken powder and decoction pieces of Angelica sinensis.Conclusion Cell-wall broken powder of Angelica sinensis has the effect of the blood enrichment but no toxic reaction. |
| Keywords: | decoction pieces of Angelica sinensis cell-wall broken powder the effect of the blood enrichment acute toxicity |
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